Electromechanochemical model of mitochondrial structure and function.
نویسندگان
چکیده
A NEW MODEL OF MITOCHONDRIAL STRUCTURE AND FUNCTION IS PROPOSED ON THE BASIS OF FOUR FUNDAMENTAL ASSUMPTIONS: (a) electrons and protons are separated in the electron transfer complexes; (b) the ATPase undergoes conformational state-transitions induced by an electric field; (c) energy is transferred by an electric field effect; and (d) a conformationally strained protein system can be relaxed via a bond-forming chemical reaction. The model can explain all of the mitochondrial coupled processes and, in addition, it provides a reasonable rationalization of the correlation between mitochondrial structure and function.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 69 3 شماره
صفحات -
تاریخ انتشار 1972